Messi, who missed training ahead of the match against Lille, was replaced by Mauro Icardi. The former Barcelona forward has yet to score a Ligue 1 goal after moving to PSG in the summer.
Teammate Mbappe, however, who had to sit out the Lille game with an infection, was included in PSG’s Champions League squad.
The French club are top of Group A with seven points from three games, with Manchester City second on six. Club Brugge are on four while Leipzig have yet to earn a point after losing all three games so far.